STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sre-5Serpentine Receptor, class E (Epsilon). (392 aa)    
Predicted Functional Partners:
sre-2
Serpentine receptor class epsilon-2.
   
  
 0.913
C14E2.6
Lipase_3 domain-containing protein.
   
   0.849
ocam-1
ONECUT (Homeobox) Associated Motif containing.
   
    0.846
srx-54
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
    0.846
nhr-174
Nuclear hormone receptor family member nhr-174; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
   
   0.798
Y22D7AR.14
WSN domain-containing protein.
   
    0.796
clec-261
C-type lectin domain-containing protein.
   
    0.796
Y6B3B.1
Uncharacterized protein.
   
   0.784
clec-234
C-type lectin domain-containing protein.
   
    0.764
mdt-22
Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
   
 
 0.743
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.