STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spl-2Sphingosine Phosphate Lyase. (542 aa)    
Predicted Functional Partners:
sphk-1
Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable).
  
 0.971
plpp-1.1
AcidPPc domain-containing protein.
    
 0.925
plpp-1.3
AcidPPc domain-containing protein.
    
 0.924
plpp-1.2
Phospholipid phosphatase homolog 1.2 homolog.
    
 0.924
spl-1
Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Essential for normal development, intestinal integrity, growth and reproduction.
  
  
0.909
pho-8
Intestinal acid PHOsphatase; Belongs to the histidine acid phosphatase family.
   
  
 0.809
emre-1
Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter (mcu-1) channel, a protein that mediates calcium uptake into mitochondria; Belongs to the SMDT1/EMRE family.
      
 0.743
Y51H4A.5
Lipase_3 domain-containing protein.
      
 0.696
pho-12
Intestinal acid PHOsphatase; Belongs to the histidine acid phosphatase family.
      
 0.693
pho-5
Putative acid phosphatase 5.
      
 0.668
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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