node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0252.1 | aap-1 | B0252.1.1 | Y110A7A.10.1 | Protein kinase domain-containing protein. | Phosphoinositide 3-kinase adapter subunit. | 0.616 |
B0252.1 | age-1 | B0252.1.1 | B0334.8a.1 | Protein kinase domain-containing protein. | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] | 0.605 |
B0252.1 | ced-2 | B0252.1.1 | Y41D4B.13a.1 | Protein kinase domain-containing protein. | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | 0.575 |
B0252.1 | gap-3 | B0252.1.1 | Y20F4.3a.1 | Protein kinase domain-containing protein. | GTPase Activating Protein family. | 0.569 |
B0252.1 | let-60 | B0252.1.1 | ZK792.6.1 | Protein kinase domain-containing protein. | Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family. | 0.528 |
B0252.1 | nck-1 | B0252.1.1 | ZK470.5a.1 | Protein kinase domain-containing protein. | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. | 0.556 |
B0252.1 | plc-3 | B0252.1.1 | T01E8.3.1 | Protein kinase domain-containing protein. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation [...] | 0.608 |
B0252.1 | rog-1 | B0252.1.1 | F54D12.6a.1 | Protein kinase domain-containing protein. | IRS-type PTB domain-containing protein. | 0.577 |
B0252.1 | sli-1 | B0252.1.1 | M02A10.3a.1 | Protein kinase domain-containing protein. | Suppressor of LIneage defect. | 0.575 |
B0252.1 | sta-1 | B0252.1.1 | Y51H4A.17a.1 | Protein kinase domain-containing protein. | Signal transducer and activator of transcription 1; Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor. | 0.578 |
aap-1 | B0252.1 | Y110A7A.10.1 | B0252.1.1 | Phosphoinositide 3-kinase adapter subunit. | Protein kinase domain-containing protein. | 0.616 |
aap-1 | age-1 | Y110A7A.10.1 | B0334.8a.1 | Phosphoinositide 3-kinase adapter subunit. | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] | 0.999 |
aap-1 | ced-2 | Y110A7A.10.1 | Y41D4B.13a.1 | Phosphoinositide 3-kinase adapter subunit. | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | 0.552 |
aap-1 | let-60 | Y110A7A.10.1 | ZK792.6.1 | Phosphoinositide 3-kinase adapter subunit. | Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family. | 0.925 |
aap-1 | nck-1 | Y110A7A.10.1 | ZK470.5a.1 | Phosphoinositide 3-kinase adapter subunit. | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. | 0.522 |
aap-1 | plc-3 | Y110A7A.10.1 | T01E8.3.1 | Phosphoinositide 3-kinase adapter subunit. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation [...] | 0.924 |
aap-1 | rog-1 | Y110A7A.10.1 | F54D12.6a.1 | Phosphoinositide 3-kinase adapter subunit. | IRS-type PTB domain-containing protein. | 0.573 |
aap-1 | sli-1 | Y110A7A.10.1 | M02A10.3a.1 | Phosphoinositide 3-kinase adapter subunit. | Suppressor of LIneage defect. | 0.886 |
aap-1 | sta-1 | Y110A7A.10.1 | Y51H4A.17a.1 | Phosphoinositide 3-kinase adapter subunit. | Signal transducer and activator of transcription 1; Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor. | 0.447 |
age-1 | B0252.1 | B0334.8a.1 | B0252.1.1 | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] | Protein kinase domain-containing protein. | 0.605 |