node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gpn-1 | slt-1 | F59D12.4.1 | F40E10.4.1 | GlyPicaN; Belongs to the glypican family. | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. | 0.502 |
gpn-1 | unc-40 | F59D12.4.1 | T19B4.7.1 | GlyPicaN; Belongs to the glypican family. | Unc-40 protein. | 0.828 |
gpn-1 | unc-5 | F59D12.4.1 | B0273.4c.1 | GlyPicaN; Belongs to the glypican family. | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | 0.892 |
gpn-1 | unc-6 | F59D12.4.1 | F41C6.1.1 | GlyPicaN; Belongs to the glypican family. | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | 0.697 |
lam-1 | unc-40 | W03F8.5a.1 | T19B4.7.1 | LAMinin related. See also lmb. | Unc-40 protein. | 0.818 |
lam-1 | unc-5 | W03F8.5a.1 | B0273.4c.1 | LAMinin related. See also lmb. | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | 0.832 |
lat-1 | slt-1 | B0457.1a.1 | F40E10.4.1 | Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. | 0.675 |
lat-1 | unc-5 | B0457.1a.1 | B0273.4c.1 | Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | 0.989 |
max-1 | unc-129 | C34B4.1b.1 | C53D6.2.2 | Motor AXon guidance. | TGF_BETA_2 domain-containing protein. | 0.411 |
max-1 | unc-40 | C34B4.1b.1 | T19B4.7.1 | Motor AXon guidance. | Unc-40 protein. | 0.558 |
max-1 | unc-5 | C34B4.1b.1 | B0273.4c.1 | Motor AXon guidance. | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | 0.827 |
max-1 | unc-6 | C34B4.1b.1 | F41C6.1.1 | Motor AXon guidance. | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | 0.553 |
plx-1 | slt-1 | Y55F3AL.1b.1 | F40E10.4.1 | Sema domain-containing protein. | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. | 0.495 |
plx-1 | unc-129 | Y55F3AL.1b.1 | C53D6.2.2 | Sema domain-containing protein. | TGF_BETA_2 domain-containing protein. | 0.624 |
plx-1 | unc-40 | Y55F3AL.1b.1 | T19B4.7.1 | Sema domain-containing protein. | Unc-40 protein. | 0.704 |
plx-1 | unc-5 | Y55F3AL.1b.1 | B0273.4c.1 | Sema domain-containing protein. | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | 0.823 |
plx-1 | unc-6 | Y55F3AL.1b.1 | F41C6.1.1 | Sema domain-containing protein. | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | 0.735 |
plx-1 | unc-73 | Y55F3AL.1b.1 | F55C7.7a.1 | Sema domain-containing protein. | Guanine nucleotide exchange factor UNC-73A. | 0.560 |
slt-1 | gpn-1 | F40E10.4.1 | F59D12.4.1 | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. | GlyPicaN; Belongs to the glypican family. | 0.502 |
slt-1 | lat-1 | F40E10.4.1 | B0457.1a.1 | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. | Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.675 |