STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pot-1Protection of telomeres homolog 1; Telomeric DNA-binding protein, which binds to single-stranded C-rich repeat sequences, with high specificity to the 5'-GCCTAA-3' sequence. Repeat sequence binding can be at the 5' or 3' telomeric end. May have a role in protecting the 5' end of the C-rich strand of the telomere. Acts redundantly with pot-2 to negatively regulate telomerase-mediated telomere extension. Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres). Through sun-1, anchors telomeres to the nucle [...] (400 aa)    
Predicted Functional Partners:
pot-2
Protection of telomeres homolog 2; Telomeric DNA-binding protein, which binds to two or more single-stranded G-rich repeat sequences (G-strand), with high specificity to the 5'-TTAGGC-3' sequence. In addition, repeat sequence binding requires a 3' single-stranded telomeric overhang. Acts redundantly with pot-1 to negatively regulate telomerase-mediated telomere extension. Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres). Does not appear to have a role in anchoring telomeres to the nuclear envelop [...]
   
  
 0.971
cTel55X.1
Uncharacterized protein.
      
 0.911
pot-3
POT1PC domain-containing protein.
   
  
 0.893
R06A4.2
Uncharacterized protein.
      
 0.850
T12E12.3
Uncharacterized protein.
      
 0.850
trt-1
Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
   
  
 0.832
mrt-1
MoRTal germline.
   
  
 0.758
clec-190
C-type LECtin.
   
  
 0.697
trf-2
MATH domain-containing protein.
      
 0.538
mrt-2
Cell cycle checkpoint protein RAD1 homolog mrt-2; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break- induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity). Belongs to the Rad1 family.
   
  
 0.479
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.