STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ntl-2NOT2_3_5 domain-containing protein. (444 aa)    
Predicted Functional Partners:
let-711
Not1 domain-containing protein.
   
 0.999
ntl-3
NOT2_3_5 domain-containing protein.
   
0.998
ntl-9
NOT-Like (Yeast CCR4/NOT complex component).
   
 0.995
ccf-1
CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family.
   
 0.994
ntl-11
NOT-Like (Yeast CCR4/NOT complex component).
   
 0.987
ntl-4
NOT-Like (Yeast CCR4/NOT complex component).
   
 0.975
ccr-4
Endo/exonuclease/phosphatase domain-containing protein.
   
 0.972
marc-6
RING-CH-type domain-containing protein.
    
 
 0.930
patr-1
Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family.
   
 
 0.916
pde-12
Endo/exonuclease/phosphatase domain-containing protein.
   
 
 0.910
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.