STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B0336.7THAP-type domain-containing protein. (501 aa)    
Predicted Functional Partners:
spr-2
Suppressor of presenilin-2; Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1. Belongs to the nucleosome assembly protein (NAP) family.
   
   0.451
ZK370.4
Uncharacterized NTE family protein ZK370.4; Belongs to the NTE family.
   
 
 0.428
hsf-1
HSF_DOMAIN domain-containing protein.
   
  
 0.412
ZK1067.3
Uncharacterized protein.
   
    0.412
pkg-2
Protein Kinase, cGMP-dependent.
   
 
 0.411
egl-4
cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...]
   
 
 0.411
M110.7
Uncharacterized NTE family protein M110.7.
   
 
 0.411
kin-2
cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family.
   
 
 0.411
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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