node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cpna-1 | lim-8 | F31D5.3b.1 | F28F5.3c.1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | LIM domain family. | 0.404 |
cpna-1 | lim-9 | F31D5.3b.1 | F25H5.1i.1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | LIM domain family. | 0.892 |
cpna-1 | pat-6 | F31D5.3b.1 | T21D12.4.1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] | 0.847 |
cpna-1 | scpl-1 | F31D5.3b.1 | B0379.4b.1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. | 0.883 |
cpna-1 | unc-89 | F31D5.3b.1 | C09D1.1b.1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] | 0.687 |
cpna-1 | unc-96 | F31D5.3b.1 | F13C5.6b.1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | Uncharacterized protein. | 0.837 |
cpna-1 | unc-97 | F31D5.3b.1 | F14D12.2.1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons. | 0.703 |
lim-8 | cpna-1 | F28F5.3c.1 | F31D5.3b.1 | LIM domain family. | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | 0.404 |
lim-8 | lim-9 | F28F5.3c.1 | F25H5.1i.1 | LIM domain family. | LIM domain family. | 0.932 |
lim-8 | pat-6 | F28F5.3c.1 | T21D12.4.1 | LIM domain family. | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] | 0.660 |
lim-8 | scpl-1 | F28F5.3c.1 | B0379.4b.1 | LIM domain family. | CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. | 0.810 |
lim-8 | uig-1 | F28F5.3c.1 | F32F2.1b.1 | LIM domain family. | PH domain-containing protein. | 0.822 |
lim-8 | unc-89 | F28F5.3c.1 | C09D1.1b.1 | LIM domain family. | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] | 0.699 |
lim-8 | unc-96 | F28F5.3c.1 | F13C5.6b.1 | LIM domain family. | Uncharacterized protein. | 0.826 |
lim-8 | unc-97 | F28F5.3c.1 | F14D12.2.1 | LIM domain family. | LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons. | 0.884 |
lim-8 | zyx-1 | F28F5.3c.1 | F42G4.3e.2 | LIM domain family. | Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development. | 0.868 |
lim-9 | cpna-1 | F25H5.1i.1 | F31D5.3b.1 | LIM domain family. | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. | 0.892 |
lim-9 | lim-8 | F25H5.1i.1 | F28F5.3c.1 | LIM domain family. | LIM domain family. | 0.932 |
lim-9 | mak-1 | F25H5.1i.1 | K08F8.1a.2 | LIM domain family. | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.408 |
lim-9 | pat-6 | F25H5.1i.1 | T21D12.4.1 | LIM domain family. | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] | 0.815 |