STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
scpl-1CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. (491 aa)    
Predicted Functional Partners:
unc-89
Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...]
   
 
 0.987
lim-9
LIM domain family.
   
 
 0.967
unc-96
Uncharacterized protein.
      
 0.902
cpna-1
Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites.
   
 
 0.883
unc-97
LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.
      
 0.858
lim-8
LIM domain family.
   
  
 0.810
pat-6
Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...]
      
 0.806
mak-1
MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
   
  
 0.760
uig-1
PH domain-containing protein.
      
 0.758
zyx-1
Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development.
   
 
 0.735
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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