STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rbg-3Rab-GAP TBC domain-containing protein. (585 aa)    
Predicted Functional Partners:
vps-29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
   
 
 0.964
tub-1
Tubby protein homolog 1; Has a role in fat regulation independent of daf-16. Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis. Functions in life span control via the insulin/IGF-1 pathway. Thought to be involved in neuronal trafficking.
    
 
 0.912
vps-35
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
   
 
 0.885
vps-26
Vacuolar protein sorting-associated protein 26; May play a role in vesicular protein sorting, similar to the yeast retromer proteins.
   
 
 0.855
F23F1.6
AA_permease_C domain-containing protein.
      
 0.850
trpp-11
Foie-gras_1 domain-containing protein.
   
  
 0.823
lpd-2
LiPid Depleted.
   
  
 0.812
lpd-3
FSA_C domain-containing protein.
   
  
 0.810
vps-51
Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS51 family.
   
  
 0.694
F59G1.8
Uncharacterized protein.
   
 
 0.684
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.