STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ubc-17Probable ubiquitin-conjugating enzyme protein 17; Belongs to the ubiquitin-conjugating enzyme family. (728 aa)    
Predicted Functional Partners:
bir-2
Baculoviral IAP repeat-containing protein bir-2.
   
 0.924
bir-1
Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...]
   
 0.924
ubc-15
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 
 0.860
ubc-8
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.825
ubc-6
UBIQUITIN_CONJUGAT_2 domain-containing protein.
      
 0.811
ubc-19
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
  
 0.811
ubc-26
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 
 0.778
ubc-25
Ubiquitin-conjugating enzyme E2 25; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function.
   
  
 0.772
ubc-23
UAS domain-containing protein.
      
 0.761
uba-1
UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family.
 
 
 0.744
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.