node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C34B7.2 | mtk-1 | C34B7.2.1 | B0414.7b.1 | SAC domain-containing protein. | Protein kinase domain-containing protein. | 0.497 |
E02D9.1 | cyp-44A1 | E02D9.1a.1 | ZK177.5.2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.416 |
E02D9.1 | mek-2 | E02D9.1a.1 | Y54E10BL.6.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.827 |
E02D9.1 | mtk-1 | E02D9.1a.1 | B0414.7b.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein. | 0.574 |
T12B3.1 | mtk-1 | T12B3.1.1 | B0414.7b.1 | TYR_PHOSPHATASE_2 domain-containing protein. | Protein kinase domain-containing protein. | 0.518 |
T12B3.1 | sax-1 | T12B3.1.1 | R11G1.4a.1 | TYR_PHOSPHATASE_2 domain-containing protein. | Serine/threonine-protein kinase sax-1; Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.787 |
cdc-14 | mtk-1 | C17G10.4h.1 | B0414.7b.1 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | Protein kinase domain-containing protein. | 0.534 |
cdc-14 | sax-1 | C17G10.4h.1 | R11G1.4a.1 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | Serine/threonine-protein kinase sax-1; Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.934 |
cyp-44A1 | E02D9.1 | ZK177.5.2 | E02D9.1a.1 | Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.416 |
cyp-44A1 | mek-2 | ZK177.5.2 | Y54E10BL.6.1 | Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.416 |
cyp-44A1 | mtk-1 | ZK177.5.2 | B0414.7b.1 | Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Protein kinase domain-containing protein. | 0.584 |
mek-2 | E02D9.1 | Y54E10BL.6.1 | E02D9.1a.1 | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.827 |
mek-2 | cyp-44A1 | Y54E10BL.6.1 | ZK177.5.2 | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.416 |
mek-2 | mtk-1 | Y54E10BL.6.1 | B0414.7b.1 | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | Protein kinase domain-containing protein. | 0.573 |
mtk-1 | C34B7.2 | B0414.7b.1 | C34B7.2.1 | Protein kinase domain-containing protein. | SAC domain-containing protein. | 0.497 |
mtk-1 | E02D9.1 | B0414.7b.1 | E02D9.1a.1 | Protein kinase domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.574 |
mtk-1 | T12B3.1 | B0414.7b.1 | T12B3.1.1 | Protein kinase domain-containing protein. | TYR_PHOSPHATASE_2 domain-containing protein. | 0.518 |
mtk-1 | cdc-14 | B0414.7b.1 | C17G10.4h.1 | Protein kinase domain-containing protein. | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | 0.534 |
mtk-1 | cyp-44A1 | B0414.7b.1 | ZK177.5.2 | Protein kinase domain-containing protein. | Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.584 |
mtk-1 | mek-2 | B0414.7b.1 | Y54E10BL.6.1 | Protein kinase domain-containing protein. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.573 |