STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clh-2Chloride channel protein. (880 aa)    
Predicted Functional Partners:
clc-2
Clc-like protein 2; Belongs to the Clc family.
      
 0.886
sulp-6
STAS domain-containing protein.
  
  
 0.714
lgc-49
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.674
lgc-48
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.622
clh-4
Chloride channel protein.
  
 
0.554
ZK643.6
Uncharacterized protein ZK643.6.
      
 0.544
lgc-47
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.529
clh-3
Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...]
  
  
0.505
acc-3
Acetylcholine-gated chloride channel subunit acc-3; Probable acetylcholine-gated chloride channel regulatory subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.481
clh-1
Chloride channel protein.
  
 
0.470
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.