STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
best-1Bestrophin homolog 1; Forms chloride channels. (450 aa)    
Predicted Functional Partners:
his-57
Histone H2A; Belongs to the histone H2A family.
      
 0.891
mec-19
Uncharacterized protein.
      
 0.850
gipc-1
PDZ domain-containing protein.
      
 0.802
glt-1
Excitatory amino acid transporter; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity).
   
  
 0.667
C23G10.11
Uncharacterized protein.
   
    0.592
T22F3.11
MFS domain-containing protein.
   
    0.591
F46C5.1
Uncharacterized protein F46C5.1.
   
    0.573
C35C5.8
Uncharacterized protein.
   
    0.538
jmjd-4
JmjC domain-containing protein.
      
 0.537
best-4
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
  
  
0.508
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.