STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
best-2Bestrophin homolog 2; Forms chloride channels. (421 aa)    
Predicted Functional Partners:
his-57
Histone H2A; Belongs to the histone H2A family.
      
 0.807
top-3
DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...]
   
  
 0.760
top-2
DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...]
      
 0.698
best-4
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
  
  
0.500
best-3
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
  
  
0.498
best-12
Bestrophin homolog 12; Forms chloride channels.
  
  
 
0.485
best-11
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
  
  
 
0.474
C09B9.85
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
  
  
 
0.471
best-25
Bestrophin homolog 25; Forms chloride channels.
  
  
 
0.468
best-10
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
  
  
 
0.467
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.