STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BE0003N10.3UBR-type domain-containing protein. (719 aa)    
Predicted Functional Partners:
bath-42
BTB and MATH domain-containing protein 42; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
   
  
 0.819
reps-1
REPS (RalBP1-associated Eps domain-containing protein) homolog.
      
 0.810
sel-5
Serine/threonine-protein kinase sel-5; Serine/threonine-protein kinase which may play a role in lin- 12-mediated cell-fate decisions.
      
 0.809
flh-1
FLYWCH-type domain-containing protein.
      
 0.758
ubql-1
Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...]
    
 
 0.705
ehs-1
Eps15 (Endocytosis protein) Homologous Sequence.
   
  
 0.668
fbxb-75
F-box domain-containing protein.
      
 0.660
R10E11.6
Uncharacterized protein R10E11.6.
   
  
 0.660
R13A5.11
Serine/threonine-protein phosphatase.
      
 0.589
itsn-1
ITSN (Intersectin) family.
    
 
 0.572
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.