STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C01B10.9Uncharacterized protein. (555 aa)    
Predicted Functional Partners:
T02G6.3
Uncharacterized protein.
      
 0.893
pde-12
Endo/exonuclease/phosphatase domain-containing protein.
   
  
 0.817
pde-3
Probable 3',5'-cyclic phosphodiesterase pde-3.
      
 0.683
pde-5
Probable 3',5'-cyclic phosphodiesterase pde-5; Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.
    
 
 0.645
pde-1
Probable 3',5'-cyclic phosphodiesterase pde-1; Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.
      
 0.625
pde-6
Probable 3',5'-cyclic phosphodiesterase pde-6; Belongs to the cyclic nucleotide phosphodiesterase family.
      
 0.613
pde-2
Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size.
   
 
 0.593
pde-4
Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP.
    
 
 0.549
C27A7.1
Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1; Probable phosphodiesterase.
  
  
 
0.526
F13H10.5
Uncharacterized protein.
  
  
 
0.526
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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