node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F07C6.4 | gmeb-1 | F07C6.4d.1 | C01B12.2.1 | FERM domain-containing protein. | SAND domain-containing protein. | 0.698 |
F07C6.4 | rnr-2 | F07C6.4d.1 | C03C10.3.1 | FERM domain-containing protein. | Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.662 |
K11H12.9 | fos-1 | K11H12.9b.1 | F29G9.4b.1 | Protein kinase domain-containing protein. | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.487 |
K11H12.9 | gmeb-1 | K11H12.9b.1 | C01B12.2.1 | Protein kinase domain-containing protein. | SAND domain-containing protein. | 0.639 |
K11H12.9 | nhr-76 | K11H12.9b.1 | C05G6.1.1 | Protein kinase domain-containing protein. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.809 |
fos-1 | K11H12.9 | F29G9.4b.1 | K11H12.9b.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Protein kinase domain-containing protein. | 0.487 |
fos-1 | gmeb-1 | F29G9.4b.1 | C01B12.2.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | SAND domain-containing protein. | 0.590 |
fos-1 | nhr-28 | F29G9.4b.1 | C11G6.4a.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Nuclear hormone receptor family member nhr-28; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. | 0.607 |
fos-1 | nhr-76 | F29G9.4b.1 | C05G6.1.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.613 |
fos-1 | nhr-77 | F29G9.4b.1 | T15D6.6.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Nuclear hormone receptor family member nhr-77; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. | 0.609 |
fos-1 | pmk-1 | F29G9.4b.1 | B0218.3.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] | 0.654 |
fos-1 | unc-62 | F29G9.4b.1 | T28F12.2a.2 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. Belongs to the TALE/MEIS homeobox family. | 0.457 |
gmeb-1 | F07C6.4 | C01B12.2.1 | F07C6.4d.1 | SAND domain-containing protein. | FERM domain-containing protein. | 0.698 |
gmeb-1 | K11H12.9 | C01B12.2.1 | K11H12.9b.1 | SAND domain-containing protein. | Protein kinase domain-containing protein. | 0.639 |
gmeb-1 | fos-1 | C01B12.2.1 | F29G9.4b.1 | SAND domain-containing protein. | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.590 |
gmeb-1 | nhr-28 | C01B12.2.1 | C11G6.4a.1 | SAND domain-containing protein. | Nuclear hormone receptor family member nhr-28; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. | 0.760 |
gmeb-1 | nhr-76 | C01B12.2.1 | C05G6.1.1 | SAND domain-containing protein. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.807 |
gmeb-1 | nhr-77 | C01B12.2.1 | T15D6.6.1 | SAND domain-containing protein. | Nuclear hormone receptor family member nhr-77; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. | 0.806 |
gmeb-1 | pmk-1 | C01B12.2.1 | B0218.3.1 | SAND domain-containing protein. | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] | 0.539 |
gmeb-1 | rnr-2 | C01B12.2.1 | C03C10.3.1 | SAND domain-containing protein. | Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.619 |