STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrfl-1Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis. May play a role in promoting fertility. (608 aa)    
Predicted Functional Partners:
aat-6
Amino acid transporter protein 6; Amino acid transporter that mediates the uptake of the L- enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility.
   
 
 0.926
gopc-1
PDZ domain-containing protein.
      
 0.916
erm-1
FERM domain-containing protein.
   
 
 0.848
aat-3
Amino Acid Transporter.
   
  
 0.763
atgp-1
Aamy domain-containing protein.
   
  
 0.735
aat-1
Amino Acid Transporter.
   
  
 0.719
nfm-1
FERM domain-containing protein.
   
 
 0.710
aat-2
Amino Acid Transporter.
   
  
 0.709
aat-4
Amino Acid Transporter.
   
  
 0.706
nhx-8
Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
      
 0.705
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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