STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
erm-1FERM domain-containing protein. (564 aa)    
Predicted Functional Partners:
ifb-2
Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.
   
  
 0.862
nrfl-1
Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis. May play a role in promoting fertility.
   
 
 0.848
dlg-1
Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family.
   
 
 0.843
let-413
Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...]
    
 
 0.843
act-5
ACTin.
   
 
 0.816
ajm-1
Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos.
   
  
 0.810
tpa-1
Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp- 29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir- 1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in phary [...]
   
 
  0.757
pkc-3
Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.
    
 
 0.749
unc-40
Unc-40 protein.
    
 0.732
sax-7
Fibronectin type-III domain-containing protein.
   
 
 0.731
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.