STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lys-7Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family. (283 aa)    
Predicted Functional Partners:
spp-1
Saposin B-type domain-containing protein.
   
  
 0.900
thn-2
THaumatiN family.
   
  
 0.897
clec-60
VWFA domain-containing protein.
   
  
 0.858
clec-87
C-type lectin domain-containing protein 87.
      
 0.850
abf-2
Antibacterial factor-related peptide 2; Exhibits antimicrobial activity against the Gram-positive bacteria B.subtilis IFO 3134, K.varians MAFF 118076 and S.aureus ATCC 6538P, the Gram-negative bacteria A.tumefaciens MAFF 1001, B.bacteriovorus MAFF 106101 and K.pneumoniae MAFF 519002, and the yeasts C.krusei MAFF 114085, K.thermotolerans MAFF 113848 and T.delbrueckii MAFF 113811.
   
  
 0.818
spp-10
SaPosin-like Protein family.
   
  
 0.815
irg-4
CUB_2 domain-containing protein.
   
  
 0.813
daf-16
Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...]
      
 0.805
pmk-1
Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...]
      
 0.801
clec-85
C-type lectin domain-containing protein.
   
  
 0.773
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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