STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tsp-17Tetraspanin-17; Protects dopaminergic neurons against oxidative stress- induced neurodegeneration. May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity. Also plays a role in modulating behaviors linked to dopamine signaling. Confers protection against oxidative stress in the whole body. (312 aa)    
Predicted Functional Partners:
elpc-3
Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...]
   
 
 0.934
elpc-1
Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family.
   
 
 0.930
elpc-2
ELongator complex Protein Component.
   
 
 0.923
tsp-16
TetraSPanin family; Belongs to the tetraspanin (TM4SF) family.
   
  
 0.895
tsp-5
Tetraspanin.
      
 0.777
ttr-33
TransThyretin-Related family domain.
      
 0.760
tsp-4
Tetraspanin.
      
 0.758
glit-1
Neuroligin-like protein glit-1; Probable neuronal cell surface protein thought to be involved in cell-cell-interactions (Probable). Confers protection against oxidative stress. Plays a role in protecting dopaminergic neurons against oxidative stress-induced neurodegeneration ; Belongs to the type-B carboxylesterase/lipase family.
      
 0.758
tsp-7
Tetraspanin.
   
  
 0.746
tsp-11
Tetraspanin.
   
  
 0.715
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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