STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tag-52Putative protein tag-52. (665 aa)    
Predicted Functional Partners:
F22G12.5
DHR-2 domain-containing protein; Belongs to the DOCK family.
   
  
 0.827
tag-77
Uncharacterized protein.
   
 
 0.819
cgef-1
DH domain-containing protein.
   
  
 0.711
pix-1
PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog.
    
 
 0.707
ceh-63
Homeobox domain-containing protein.
      
 0.697
F46H5.4
Uncharacterized protein; Belongs to the DOCK family.
   
  
 0.689
Y95B8A.12
Pleckstrin homology and RHoGef (RhoGEF) domain containing.
      
 0.551
bmk-1
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
    0.506
mig-2
Rac-like GTPase.
  
 
 
 0.493
ced-10
Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...]
  
 
 
 0.422
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.