STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lmp-1LAMP family protein lmp-1; Belongs to the LAMP family. (237 aa)    
Predicted Functional Partners:
let-363
Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...]
    
 
 0.898
nprl-2
Nitrogen Permease Regulator Like homolog.
    
 
 0.890
daf-15
Raptor_N domain-containing protein.
    
 
 0.865
npp-20
Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family.
    
 
 0.865
nprl-3
GATOR complex protein NPRL3; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
   
 
 0.862
rab-7
RAB family.
   
 
 0.860
Y32H12A.8
WD_REPEATS_REGION domain-containing protein.
    
 
 0.856
T08A11.1
DEP domain-containing protein.
    
 
 0.855
F39C12.1
Zinc_ribbon_16 domain-containing protein.
   
   0.852
npp-18
Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus.
   
   0.852
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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