STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
asfl-1Probable histone chaperone asf-1-like protein; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (245 aa)    
Predicted Functional Partners:
tlk-1
Serine/threonine-protein kinase tousled-like 1; Essential for appropriate transcription during embryonic development. May act during transcription elongation to activate the RNA polymerase II large subunit (ama-1) by phosphorylating the Ser-2 residues of the C-terminal domain 7-residue repeats. Does not phosphorylate histone H3.
   
 
 0.954
chaf-2
WD_REPEATS_REGION domain-containing protein.
   
 
 0.953
hira-1
Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.
   
 
 0.936
chaf-1
CHromatin Assembly Factor.
   
 
 0.914
mcm-2
DNA helicase; Belongs to the MCM family.
   
 
 0.908
nasp-2
SHNi-TPR domain-containing protein.
   
 
 0.863
rba-1
Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
   
 
 0.855
nasp-1
SHNi-TPR domain-containing protein.
   
 
 0.850
hat-1
Hat1_N domain-containing protein.
   
 
 0.831
M28.5
NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family.
   
    0.798
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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