STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-147Nuclear Hormone Receptor family. (373 aa)    
Predicted Functional Partners:
gei-8
Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
    
 0.651
bar-1
Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...]
  
 
 0.533
F19F10.1
ETS domain-containing protein.
  
 
   0.529
ast-1
ETS domain-containing protein.
  
   0.529
lin-1
ETS domain-containing protein.
  
 
   0.524
ets-7
ETS domain-containing protein.
  
 
   0.523
ets-5
ETS domain-containing transcription factor ets-5; Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons. The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels. Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons. Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons. May mediate tra [...]
  
   0.521
mom-2
Protein mom-2; Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in cleavage axis determination. Binds to receptor tyrosine kinase cam-1. Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18. May act redundantly with other Wnt ligands such [...]
  
     0.521
nhr-82
Nuclear Hormone Receptor family.
  
     0.519
nhr-81
Nuclear Hormone Receptor family.
  
     0.518
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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