STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
adm-2ADAM (Disintegrin plus metalloprotease) family. (952 aa)    
Predicted Functional Partners:
F42F12.3
3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
   
  
 0.702
C37H5.5
Nucleolar complex protein 3 homolog.
      
 0.699
nekl-3
Serine/threonine-protein kinase nekl-3; Probable serine/threonine-protein kinase required for the completion of molting; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
      
 0.693
rrp-1
Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA. Belongs to the RRP1 family.
      
 0.692
ttr-30
TransThyretin-Related family domain.
      
 0.665
scav-2
SCAVenger receptor (CD36 family) related; Belongs to the CD36 family.
   
  
 0.665
mrps-17
28S ribosomal protein S17, mitochondrial; Belongs to the universal ribosomal protein uS17 family.
      
 0.664
nifk-1
RRM domain-containing protein.
      
 0.663
cogc-2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function.
      
 0.662
tads-1
Rtf2 domain-containing protein.
      
 0.660
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.