STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tbc-6Growth hormone-regulated TBC protein 6. (330 aa)    
Predicted Functional Partners:
arf-1.2
ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis.
   
 0.582
arf-1.1
ADP-ribosylation factor 1-like 1; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family.
   
 0.582
arf-3
ADP-ribosylation factor related (20.5 kD) (Arf-3); Belongs to the small GTPase superfamily. Arf family.
   
 0.582
tbc-3
Rab-GAP TBC domain-containing protein.
      
 0.562
C27F2.10
PCI domain-containing protein 2 homolog; Belongs to the CSN12 family.
 
    
 0.522
cdc-14
Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...]
    
 
 0.521
T12B3.1
TYR_PHOSPHATASE_2 domain-containing protein.
    
 
 0.521
snb-5
Synaptobrevin-like protein 5.
     
 0.513
snb-6
V-SNARE coiled-coil homology domain-containing protein.
     
 0.513
snb-7
V-SNARE coiled-coil homology domain-containing protein.
     
 0.513
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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