STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C04E12.4Uncharacterized protein. (609 aa)    
Predicted Functional Partners:
eef-1G
Probable elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.
   
 
 0.556
prdx-2
Thioredoxin domain-containing protein.
  
 
 0.516
prdx-3
Probable peroxiredoxin prdx-3; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
  
 
 0.516
Y22D7AL.10
Uncharacterized protein; Belongs to the GroES chaperonin family.
  
 
 0.502
msra-1
PMSR domain-containing protein.
  
 
 0.471
trx-2
Probable thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
   
 
 0.457
trxr-1
Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting.
  
 
 0.445
trxr-2
Probable glutathione reductase 2; Maintains high levels of reduced glutathione in the cytosol.
  
 
 0.445
Y71H2AR.1
DUF953 domain-containing protein.
   
  
 0.422
prdx-6
Thioredoxin domain-containing protein.
  
 
 0.415
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.