STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C04E6.5USP domain-containing protein. (515 aa)    
Predicted Functional Partners:
wdr-48
WD repeat-containing protein 48 homolog; Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.
    
 
 0.782
wdr-20
WD repeat-containing protein 20 homolog; Together with wdr-48, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.
    
 
 0.717
ZK354.6
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
    0.615
C09B9.4
Protein kinase domain-containing protein.
   
    0.613
C18E9.8
Uncharacterized protein.
   
    0.613
acs-18
AMP-binding domain-containing protein.
   
 
 0.612
F42A9.7
Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
   
    0.608
T22C1.8
Tyrosine-protein phosphatase.
   
  
 0.599
wht-5
ABC transporter domain-containing protein.
   
  
 0.597
Y40H4A.2
SER_THR_PHOSPHATASE domain-containing protein.
   
    0.596
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.