STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mpk-2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (605 aa)    
Predicted Functional Partners:
srw-145
G_PROTEIN_RECEP_F1_2 domain-containing protein.
    
 
 0.738
H43E16.1
Uncharacterized protein.
   
 
 0.732
H02F09.3
Uncharacterized protein.
   
 
 0.716
mak-2
MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
  
 
0.691
C25H3.10
F-box domain-containing protein.
   
  
 0.677
H02F09.2
Uncharacterized protein.
   
  
 0.674
sek-4
Protein kinase domain-containing protein.
  
 
 0.667
lgc-11
Acetylcholine receptor (51.1 kD) (Acr-22); Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.665
mek-2
Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1.
  
 
0.651
E02D9.1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
0.639
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.