STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyls-1Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family. (274 aa)    
Predicted Functional Partners:
sas-4
Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size.
   
 
 0.923
dyf-19
Uncharacterized protein.
      
 0.912
ccep-290
CEntrosomal Protein.
      
 0.891
fbf-1
Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...]
   
  
 0.803
mksr-2
MecKel Syndrome 1 (MKS1)-Related.
      
 0.760
K10G6.4
Uncharacterized protein.
   
  
 0.745
sas-6
Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication.
   
  
 0.723
daf-19
RFX-like transcription factor daf-19; May be a transcription factor that regulates some genes of ciliated sensory neurons. May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression; Belongs to the RFX family.
   
  
 0.700
che-11
Uncharacterized protein.
      
 0.697
gasr-8
GAS (Human Growth Arrest-Specific) Related.
      
 0.693
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.