STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nas-4Zinc metalloproteinase nas-4; Metalloprotease (By similarity). May be involved in digestion. (365 aa)    
Predicted Functional Partners:
kmo-2
FAD_binding_3 domain-containing protein.
      
 0.664
gei-4
GEX Interacting protein.
      
 0.660
lonp-1
Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mi [...]
      
 0.549
kmo-1
Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
      
 0.461
C34F6.1
Uncharacterized protein.
   
    0.432
pept-2
Peptide transporter family 2; Proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides. Transport is independent of sodium and chloride ions. Protein shows high affinity to peptide substrates. Belongs to the PTR2/POT transporter (TC 2.A.17) family.
   
  
 0.426
col-128
COLlagen.
   
    0.424
rom-3
Rhomboid domain-containing protein.
      
 0.420
nas-9
Zinc metalloproteinase nas-9; Metalloprotease.
  
   
0.416
rom-4
Rhomboid domain-containing protein.
      
 0.416
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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