STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bas-1Biogenic Amine Synthesis related. (523 aa)    
Predicted Functional Partners:
tph-1
BH4_AAA_HYDROXYL_2 domain-containing protein.
   
 0.993
tbh-1
Tyramine beta-hydroxylase; Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity. Belongs to the copper type II ascorbate-dependent monooxygenase family.
     
 0.980
pah-1
Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan. Plays a role in the biosynthesis of a melanin-like cuticle pigment. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
   
 0.958
cat-2
Tyrosine 3-monooxygenase; Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior.
   
 0.946
tyr-4
TYRosinase.
   
 0.936
tatn-1
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
  
 
 0.919
got-1.2
Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system.
   
 
 0.919
got-2.2
Aspartate aminotransferase.
   
 
 0.912
got-2.1
Aspartate aminotransferase.
   
 
 0.912
tdc-1
Tyrosine decarboxylase; Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling ; Belongs to the group II decarboxylase family.
  
  
0.912
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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