STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xnd-1X chromosome NonDisjunction factor. (702 aa)    
Predicted Functional Partners:
him-17
High Incidence of Males (Increased X chromosome loss).
   
  
 0.905
dsb-2
Double-Strand Break factor.
   
  
 0.824
dsb-1
Double-Strand Break factor.
   
  
 0.816
rec-1
Uncharacterized protein.
   
  
 0.816
htp-3
HORMA domain-containing protein.
   
  
 0.811
spo-11
Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.
   
  
 0.796
rad-54
Uncharacterized protein.
   
 
 0.731
syp-2
Uncharacterized protein.
   
  
 0.725
rad-51
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA.
   
  
 0.721
cra-1
N-terminal acetyltransferase B complex subunit NAA25 homolog; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Required for chromosome organization and arrangement; specifically for assembly of the central region components of the synaptonemal complex onto chromosomes during meiosis and for DNA double stranded break formation and repair. Acts downstream of xnd-1 to regulate levels of histone acetylation in germ and somatic cell nuclei by controlling acetyl-CoA produ [...]
   
  
 0.715
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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