STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icl-1Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family. (968 aa)    
Predicted Functional Partners:
mdh-2
Probable malate dehydrogenase, mitochondrial.
  
 0.999
aco-2
Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.999
cts-1
Probable citrate synthase, mitochondrial.
  
 0.999
aco-1
Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.999
acs-19
Acetyl-coenzyme A synthetase.
  
 0.998
mdh-1
Malate dehydrogenase.
  
 
 0.998
men-1
Malic enzyme.
  
 
 0.997
agxt-1
Serine--pyruvate aminotransferase.
  
 
 0.994
F41E6.5
FMN hydroxy acid dehydrogenase domain-containing protein.
  
 
 0.993
fum-1
Probable fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
    
 0.991
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (24%) [HD]