node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0261.1 | fos-1 | B0261.1.1 | F29G9.4b.1 | SANT domain-containing protein. | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.439 |
B0261.1 | nhr-76 | B0261.1.1 | C05G6.1.1 | SANT domain-containing protein. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.699 |
K11H12.9 | fos-1 | K11H12.9b.1 | F29G9.4b.1 | Protein kinase domain-containing protein. | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.487 |
K11H12.9 | gmeb-1 | K11H12.9b.1 | C01B12.2.1 | Protein kinase domain-containing protein. | SAND domain-containing protein. | 0.639 |
K11H12.9 | nhr-76 | K11H12.9b.1 | C05G6.1.1 | Protein kinase domain-containing protein. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.809 |
atgl-1 | mod-1 | C05D11.7b.2 | K06C4.6a.1 | Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] | Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.580 |
atgl-1 | nhr-49 | C05D11.7b.2 | K10C3.6c.2 | Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.699 |
atgl-1 | nhr-76 | C05D11.7b.2 | C05G6.1.1 | Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.634 |
atgl-1 | ser-6 | C05D11.7b.2 | Y54G2A.35a.1 | Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.616 |
fos-1 | B0261.1 | F29G9.4b.1 | B0261.1.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | SANT domain-containing protein. | 0.439 |
fos-1 | K11H12.9 | F29G9.4b.1 | K11H12.9b.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Protein kinase domain-containing protein. | 0.487 |
fos-1 | gmeb-1 | F29G9.4b.1 | C01B12.2.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | SAND domain-containing protein. | 0.590 |
fos-1 | nhr-76 | F29G9.4b.1 | C05G6.1.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.613 |
fos-1 | unc-62 | F29G9.4b.1 | T28F12.2a.2 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. Belongs to the TALE/MEIS homeobox family. | 0.457 |
gei-8 | nhr-49 | C14B9.6a.3 | K10C3.6c.2 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.610 |
gei-8 | nhr-76 | C14B9.6a.3 | C05G6.1.1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.577 |
gmeb-1 | K11H12.9 | C01B12.2.1 | K11H12.9b.1 | SAND domain-containing protein. | Protein kinase domain-containing protein. | 0.639 |
gmeb-1 | fos-1 | C01B12.2.1 | F29G9.4b.1 | SAND domain-containing protein. | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.590 |
gmeb-1 | nhr-76 | C01B12.2.1 | C05G6.1.1 | SAND domain-containing protein. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.807 |
gmeb-1 | unc-62 | C01B12.2.1 | T28F12.2a.2 | SAND domain-containing protein. | Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. Belongs to the TALE/MEIS homeobox family. | 0.547 |