STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ckk-1Calcium/calmodulin-dependent protein kinase kinase; Calcium/calmodulin-dependent protein kinase which phosphorylates cmk-1. Component of a calcium-triggered signaling cascade involved in CRE-mediated transcriptional activation, probably through cmk-1-mediated crh-1/CREB phosphorylation. (541 aa)    
Predicted Functional Partners:
cal-2
CALmodulin related genes.
   
 0.952
cmd-1
Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
   
 
 0.917
cal-4
CALmodulin related genes.
   
 
 0.851
cal-1
Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function.
   
 
 0.847
B0563.7
Uncharacterized calcium-binding protein B0563.7.
    
 
 0.844
cal-7
EF-hand domain-containing protein.
    
 
 0.844
K03A1.4
EF-hand domain-containing protein.
    
 
 0.844
cal-3
CALmodulin related genes.
    
 
 0.844
aakg-1
AMP-Activated protein Kinase Gamma subunit.
   
 
 0.807
utx-1
UTX (Ubiquitously transcribed TPR on X) homolog.
      
 0.670
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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