STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glr-4GLutamate Receptor family (AMPA). (951 aa)    
Predicted Functional Partners:
ser-4
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
  
 0.801
cfi-1
AT-rich interactive domain-containing protein cfi-1; Transcription factor which regulates neuronal subtype identity. Promotes differentiation of URA sensory neurons and prevents them to express male-specific CEM features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression.
   
  
 0.742
trp-4
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.723
unc-3
Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.
   
  
 0.713
acr-15
AcetylCholine Receptor.
  
   
 0.710
del-1
Degenerin del-1; Probable sodium channel subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
  
 0.698
cho-1
High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent.
   
  
 0.673
bnc-1
BasoNuClin-1 zinc finger protein homolog.
      
 0.662
sra-36
Serpentine Receptor, class A (Alpha).
      
 0.655
glr-5
GLutamate Receptor family (AMPA).
  
 
0.635
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (12%) [HD]