STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
doxa-1Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. (397 aa)    
Predicted Functional Partners:
bli-3
Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...]
  
 
 0.970
duox-2
DUal OXidase.
  
 
 0.930
tsp-15
Tetraspanin-15; Plays a role in cuticle biogenesis. In complex with doxa-1 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix ; Belongs to the tetraspanin (TM4SF) family.
   
  
 0.909
mlt-7
Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.
   
  
 0.901
skpo-3
ShKT domain-containing protein.
   
  
 0.761
skpo-2
ShK domain and PerOxidase domain containing protein.
   
  
 0.758
ZK822.5
Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
  
 0.734
F52H2.4
Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      
 0.728
tsp-8
Tetraspanin.
   
  
 0.721
tsp-6
Tetraspanin.
      
 0.719
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.