STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C06G4.1KH domain-containing protein C06G4.1. (886 aa)    
Predicted Functional Partners:
rack-1
Guanine nucleotide-binding protein subunit beta-2-like 1; Required for the expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.
   
 
 0.624
dnj-11
DNaJ domain (Prokaryotic heat shock protein).
   
   0.556
eef-1G
Probable elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.
   
   0.540
cgh-1
ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
   
 
 0.512
syp-4
Synaptonemal complex protein 4; Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination.
   
 
 0.510
sec-61
Plug_translocon domain-containing protein.
   
    0.463
wrn-1
Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity).
   
   0.457
aos-1
SUMO-activating enzyme subunit aos-1; The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).
   
 
 0.438
tsn-1
Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.
   
  
 0.437
drsh-1
Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family.
   
    0.433
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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