STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clp-1Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death. (780 aa)    
Predicted Functional Partners:
nhx-9
Probable Na(+)/H(+) antiporter nhx-9; Serves some physiological function other than regulation of cellular pH.
      
 0.692
F30F8.9
LETM1 domain-containing protein.
      
 0.690
swip-10
Lactamase_B domain-containing protein.
      
 0.660
asp-3
Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.
   
  
 0.630
M57.2
Uncharacterized protein.
   
  
 0.622
bet-2
BET (Two bromodomains) family protein.
   
 
 0.586
pcf-11
Polyadenylation and cleavage factor homolog 11.
   
  
 0.568
asp-4
Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.
   
  
 0.567
M04F3.4
Uncharacterized protein.
   
 
 0.490
wrt-3
Warthog protein 3; Intercellular signal essential for a variety of patterning events during development.
      
 0.467
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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