STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ncx-6Putative sodium/calcium exchanger 6. (590 aa)    
Predicted Functional Partners:
ncx-2
Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.868
ncx-1
Sodium-calcium exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.832
ncx-3
Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.832
srh-127
Serpentine Receptor, class H.
      
 0.806
sre-43
Serpentine Receptor, class E (Epsilon).
      
 0.741
srt-47
Serpentine Receptor, class T.
      
 0.724
clhm-1
Calcium homeostasis modulator protein; Pore-forming subunit of a voltage-gated ion channel. Permeable to monovalent cations, divalent cations and anions with selectivity Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). Acts both as a voltage-gated and calcium-activated ion channel. Required for normal locomotion; Belongs to the CALHM family.
      
 0.671
mcu-1
Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Required for rapid mitochondrial calcium uptake and mitochondrial reactive oxygen species (mtROS) production after wounding.
      
 0.469
srh-234
Serpentine Receptor, class H.
      
 0.463
sca-1
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
  
 
 0.452
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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