STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cux-7Clk-2 Upstream, human gene XE7 related. (495 aa)    
Predicted Functional Partners:
Y66D12A.10
MIT_C domain-containing protein.
   
  
 0.649
mrpl-30
Mitochondrial Ribosomal Protein, Large.
   
  
 0.647
F46B6.4
Hflx-type G domain-containing protein.
   
  
 0.606
eat-17
Rab-GAP TBC domain-containing protein.
      
 0.571
dod-18
Downstream Of DAF-16 (Regulated by DAF-16).
   
  
 0.565
unc-50
Protein unc-50; Required for cell surface expression of acetylcholine receptors in body-wall muscles.
      
 0.521
T22C1.6
Uncharacterized protein.
   
  
 0.458
txdc-9
Thioredoxin domain-containing protein 9; Required for normal microtubule organization and function. Regulates tubulin acetylation in ALM and PLM neurons.
   
  
 0.420
clk-2
Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family.
 
 
    0.407
R166.3
Uncharacterized protein R166.3.
      
 0.406
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.