node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ctl-1 | ctl-2 | Y54G11A.6.2 | Y54G11A.5.2 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | 0.948 |
ctl-1 | daf-16 | Y54G11A.6.2 | R13H8.1h.1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.809 |
ctl-1 | daf-2 | Y54G11A.6.2 | Y55D5A.5c.2 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] | 0.705 |
ctl-1 | gst-4 | Y54G11A.6.2 | K08F4.7.1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. | 0.812 |
ctl-1 | sod-1 | Y54G11A.6.2 | C15F1.7a.1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Required for normal brood size. May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation. | 0.709 |
ctl-1 | sod-2 | Y54G11A.6.2 | F10D11.1.2 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Superoxide dismutase [Mn] 1, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | 0.693 |
ctl-1 | sod-3 | Y54G11A.6.2 | C08A9.1.1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Superoxide dismutase [Mn] 2, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | 0.903 |
ctl-1 | sod-4 | Y54G11A.6.2 | F55H2.1b.1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Extracellular superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.767 |
ctl-1 | sod-5 | Y54G11A.6.2 | ZK430.3.1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. | 0.924 |
ctl-2 | ctl-1 | Y54G11A.5.2 | Y54G11A.6.2 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | 0.948 |
ctl-2 | daf-16 | Y54G11A.5.2 | R13H8.1h.1 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.805 |
ctl-2 | daf-2 | Y54G11A.5.2 | Y55D5A.5c.2 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] | 0.701 |
ctl-2 | gst-4 | Y54G11A.5.2 | K08F4.7.1 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. | 0.751 |
ctl-2 | sod-1 | Y54G11A.5.2 | C15F1.7a.1 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Required for normal brood size. May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation. | 0.858 |
ctl-2 | sod-2 | Y54G11A.5.2 | F10D11.1.2 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Superoxide dismutase [Mn] 1, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | 0.755 |
ctl-2 | sod-3 | Y54G11A.5.2 | C08A9.1.1 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Superoxide dismutase [Mn] 2, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | 0.901 |
ctl-2 | sod-4 | Y54G11A.5.2 | F55H2.1b.1 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Extracellular superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.618 |
ctl-2 | sod-5 | Y54G11A.5.2 | ZK430.3.1 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. | 0.922 |
daf-16 | ctl-1 | R13H8.1h.1 | Y54G11A.6.2 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. | 0.809 |
daf-16 | ctl-2 | R13H8.1h.1 | Y54G11A.5.2 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. | 0.805 |