STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrf-6Nose resistant to fluoxetine protein 6; Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development; Belongs to the acyltransferase 3 family. (822 aa)    
Predicted Functional Partners:
nrf-5
Nose resistant to fluoxetine protein 5; Plays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues. Possesses lipid transfer activity. Mediates transport of lipids from intestine to reproductive tract. Binds phosphatidylserine. Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells. Vital for embryonic development.
   
  
 0.813
ndg-4
NRF domain-containing protein.
  
  
0.712
dhs-7
DeHydrogenases, Short chain.
   
  
 0.670
lbp-8
FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
   
  
 0.550
avr-15
Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.474
glc-1
Glutamate-gated chloride channel alpha; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. P [...]
      
 0.467
bus-1
Acyl_transf_3 domain-containing protein.
      
 0.465
F18C12.4
Uncharacterized protein.
      
 0.461
nhr-41
Nuclear hormone receptor family member nhr-41; Orphan nuclear receptor that may have a role in dauer formation; Belongs to the nuclear hormone receptor family.
      
 0.461
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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