STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rap-3RAP homolog (Vertebrate Rap GTPase family). (205 aa)    
Predicted Functional Partners:
shn-1
Protein shank; Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions. Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density. The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4. Plays a role in the regulation of the defecation cycle, and this may be in as [...]
  
 
 0.870
ZK669.5
Uncharacterized protein.
    
 
 0.832
lin-45
Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
   
 
 0.775
C34D4.2
Serine/threonine-protein phosphatase.
   
 
 0.745
epac-1
Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.
    
 
 0.721
msp-3
Major sperm protein 3; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
   
 
 0.715
oac-15
Acyl_transf_3 domain-containing protein.
    
 
 0.700
F01D4.5
PHD-type domain-containing protein.
    
 
 0.698
srh-281
Serpentine Receptor, class H.
      
 0.692
lam-2
Laminin-like protein lam-2; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3.
   
 
 0.684
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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