STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ipp-5Probable type I inositol 1,4,5-trisphosphate 5-phosphatase; Protein IPP-5 (ipp-5) mRNA, complete cds; Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family (409 aa)    
Predicted Functional Partners:
lfe-2
Inositol-trisphosphate 3-kinase homolog; Probably by regulating inositol 1,4,5-trisphosphate levels, negatively regulates posterior body wall muscle contractions required for defecation and let-23 signaling pathway that controls spermathecal dilation and ovulation. May also regulate ovulation downstream of actin cross-linker fln-1
   
 
 0.986
egl-8
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...]
   
 
 0.976
plc-3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation [...]
   
 
 0.973
ipmk-1
Kinase; Protein ZK795.1 (ZK795.1) mRNA, complete cds; Belongs to the inositol phosphokinase (IPK) family
     
 0.971
plc-1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity (By similarity). By activating IP3 receptor itr-1-mediated intracellular Ca(2+) release via the production of IP3, regulates ovulation by controlling contraction and/or dilation of the di [...]
   
 
 0.932
plc-4
Phosphoinositide phospholipase C; Protein PLC-4 (plc-4) mRNA, complete cds
   
 
 0.922
itr-1
Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...]
   
  
 0.875
T25B9.10
INositol Polyphosphate-5-Phosphatase; Protein T25B9.10, isoform b (T25B9.10) mRNA, complete cds
   
  
 0.866
ttx-7
Inositol monophosphatase ttx-7; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Required in central interneurons of the mature nervous system for correct localization of synaptic components. Required for thermotaxis
      
 0.811
cil-1
Inositol polyphosphate 5-phosphatase; Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2; Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family
      
 0.806
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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