node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acn-1 | mlt-10 | C42D8.5a.2 | C09E8.3.1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | Uncharacterized protein. | 0.641 |
acn-1 | mlt-11 | C42D8.5a.2 | W01F3.3b.1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | Uncharacterized protein. | 0.859 |
acn-1 | mlt-8 | C42D8.5a.2 | W08F4.6.1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | Uncharacterized protein. | 0.868 |
acn-1 | mlt-9 | C42D8.5a.2 | F09B12.1a.1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | Uncharacterized protein. | 0.715 |
acn-1 | nhr-23 | C42D8.5a.2 | C01H6.5a.1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.670 |
acn-1 | ptr-4 | C42D8.5a.2 | C45B2.7.1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | SSD domain-containing protein. | 0.861 |
acn-1 | qua-1 | C42D8.5a.2 | T05C12.10.1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. | 0.639 |
lin-42 | mlt-10 | F47F6.1d.1 | C09E8.3.1 | Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...] | Uncharacterized protein. | 0.714 |
lin-42 | nhr-23 | F47F6.1d.1 | C01H6.5a.1 | Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...] | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.567 |
mlt-10 | acn-1 | C09E8.3.1 | C42D8.5a.2 | Uncharacterized protein. | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | 0.641 |
mlt-10 | lin-42 | C09E8.3.1 | F47F6.1d.1 | Uncharacterized protein. | Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...] | 0.714 |
mlt-10 | mlt-11 | C09E8.3.1 | W01F3.3b.1 | Uncharacterized protein. | Uncharacterized protein. | 0.784 |
mlt-10 | mlt-2 | C09E8.3.1 | C01H6.2.1 | Uncharacterized protein. | ANK_REP_REGION domain-containing protein. | 0.665 |
mlt-10 | mlt-8 | C09E8.3.1 | W08F4.6.1 | Uncharacterized protein. | Uncharacterized protein. | 0.870 |
mlt-10 | mlt-9 | C09E8.3.1 | F09B12.1a.1 | Uncharacterized protein. | Uncharacterized protein. | 0.819 |
mlt-10 | nas-37 | C09E8.3.1 | C17G1.6a.1 | Uncharacterized protein. | Zinc metalloproteinase nas-37; Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Required during ecdysis, the opening of the cuticle to allow the worm to escape. | 0.671 |
mlt-10 | nhr-23 | C09E8.3.1 | C01H6.5a.1 | Uncharacterized protein. | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.740 |
mlt-10 | ptr-4 | C09E8.3.1 | C45B2.7.1 | Uncharacterized protein. | SSD domain-containing protein. | 0.680 |
mlt-10 | qua-1 | C09E8.3.1 | T05C12.10.1 | Uncharacterized protein. | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. | 0.781 |
mlt-11 | acn-1 | W01F3.3b.1 | C42D8.5a.2 | Uncharacterized protein. | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] | 0.859 |