STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mlt-10Uncharacterized protein. (690 aa)    
Predicted Functional Partners:
mlt-8
Uncharacterized protein.
   
  
 0.870
mlt-9
Uncharacterized protein.
   
  
 0.819
mlt-11
Uncharacterized protein.
   
 
 0.784
qua-1
Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development.
   
 
 0.781
nhr-23
Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily.
      
 0.740
lin-42
Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...]
   
  
 0.714
ptr-4
SSD domain-containing protein.
   
  
 0.680
nas-37
Zinc metalloproteinase nas-37; Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Required during ecdysis, the opening of the cuticle to allow the worm to escape.
   
  
 0.671
mlt-2
ANK_REP_REGION domain-containing protein.
   
 
 0.665
acn-1
Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...]
   
  
 0.641
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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