STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mks-5Protein fantom; Thought to have an important role in cilia formation and cilia-mediated chemosensation. Involved in the docking of other MKS/MKSR proteins localized to the transition zone of the cilia. Belongs to the RPGRIP1 family. (1322 aa)    
Predicted Functional Partners:
nphp-4
NePHronoPhthisis (Human kidney disease) homolog.
   
 
 0.998
nphp-1
Nephrocystin-1-like protein; May be necessary for initial assembly of the cilium.
   
 
 0.995
tmem-231
TMEM (Human TransMEMbrane protein) homolog.
   
  
 0.907
mks-6
C2 domain-containing protein.
   
  
 0.886
jbts-14
Transmembrane protein 237 homolog; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family.
   
 
 0.810
tmem-17
TMEM (Human TransMEMbrane protein) homolog.
   
  
 0.776
col-42
Col_cuticle_N domain-containing protein.
      
 0.773
mks-3
MecKel-Gruber Syndrome (MKS) homolog.
   
  
 0.766
bbs-1
Bardet-Biedl syndrome 1 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme.
   
  
 0.747
mks-2
MecKel-Gruber Syndrome (MKS) homolog.
   
  
 0.738
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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