STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hda-4Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development. (869 aa)    
Predicted Functional Partners:
mef-2
MADS-box domain-containing protein.
   
 
 0.924
kin-29
Serine/threonine-protein kinase kin-29; Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages.
   
 
 0.883
mys-2
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
    
 
 0.766
hda-2
Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...]
  
 
 
0.755
mrg-1
MRG domain-containing protein.
   
 
 0.753
hda-3
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
  
 
 
0.746
pola-1
DNA polymerase.
     
 0.712
T20D4.12
DUF19 domain-containing protein.
      
 0.700
T20D4.11
DUF19 domain-containing protein.
      
 0.693
C17B7.4
DUF19 domain-containing protein.
      
 0.692
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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